Genetic architecture

From Cosmopedia

Genetic architecture refers to the underlying genetic basis of a phenotypic trait. A synonymous term is the `genotype-phenotype map', the way that genotypes map to the phenotypes.

The genotype-phenotype map has been analyzed in terms of several principle axes: epistasis, polygeny, pleiotropy, quasi-continuity, modularity, phenotypic plasticity, robustness, and evolvability.

  • When the alleles at one locus change the phenotypic effects of genetic variation at another locus, the two genes are said to exhibit `epistasis' in their interactions.
  • When multiple genes contribute to a particular phenotypic character, the map is said to possess `polygeny'. The genetic architecture in cases of polygeny can be further characterized by the spectrum of contributions of the genes, e.g. many genes of small effect vs. few genes of large effect.
  • When multiple phenotypic characters are affected by a single genetic variation, the map is said to possess `pleiotropy'.
  • When small genetic changes map to small phenotypic changes, the map is said to possess `quasi-continuity' (Lewontin).
  • When two different phenotypic characters can be mapped to mostly non-overlapping sets of genes, the map is said to possess `modularity', though this concept is still in flux in the scientific literature.
  • When a single genotype gives rise to a spectrum of phenotypes, the phenotype is said to have `plasticity'. The plasticity may occur as different phenotypes among different individuals of the same genotype, or different phenotypes within the lifetime of a single individual, or different phenotypes in response to specific environmental conditions.
  • When the same phenotype occurs in an organism despite a variety of environmental perturbations, it is said to be `robust'. When the same phenotype is produced despite mutations in the genes involved it its production, it is said to possess 'mutational robustness'.
  • When there is a significant chance that genetic variation can be produced which produces a net increase in adaptation in an organism, the genotype-phenotype map is said to have `evolvability'.